{"id":6704,"date":"2025-09-03T11:51:34","date_gmt":"2025-09-03T09:51:34","guid":{"rendered":"https:\/\/mediconomics.com\/glossar\/null-hypothesis-h0\/"},"modified":"2025-09-03T11:51:34","modified_gmt":"2025-09-03T09:51:34","slug":"null-hypothesis-h0","status":"publish","type":"glossary","link":"https:\/\/mediconomics.com\/en\/glossar\/null-hypothesis-h0\/","title":{"rendered":"Null hypothesis (H0)"},"content":{"rendered":"<p>The null hypothesis (H0) is a fundamental statement in statistical hypothesis testing. It postulates that there is no effect, no association, or no difference between the groups under investigation. In a typical clinical trial, the null hypothesis might, for example, be: &#8220;There is no difference in efficacy between the new investigational medicinal product and placebo.&#8221;  <\/p>\n<p>The entire statistical testing procedure is designed to gather evidence against the null hypothesis. Researchers aim to refute the null hypothesis (to &#8220;reject&#8221; it). If the data obtained from the study are so unlikely that, assuming the null hypothesis is true, they would occur only rarely (typically with a probability of less than 5%, the p-value), the null hypothesis is rejected. This leads to acceptance of the alternative hypothesis (H1), which states that an effect does in fact exist. The precise formulation of H0 is a crucial first step for biostatisticians at a CRO when planning the statistical analysis.    <\/p>\n<p><a href=\"https:\/\/mediconomics.com\/glossary\/\">Back to overview<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The null hypothesis (H0) is a fundamental statement in statistical hypothesis testing. It postulates that there is no effect, no association, or no difference between the groups under investigation. In a typical clinical trial, the null hypothesis might, for example, be: &#8220;There is no difference in efficacy between the new investigational medicinal product and placebo.&#8221; [&hellip;]<\/p>\n","protected":false},"author":10,"featured_media":0,"parent":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"glossary-cat":[],"class_list":["post-6704","glossary","type-glossary","status-publish","hentry"],"acf":[],"related_terms":"","external_url":"","internal_reference_id":"","_links":{"self":[{"href":"https:\/\/mediconomics.com\/en\/wp-json\/wp\/v2\/glossary\/6704","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mediconomics.com\/en\/wp-json\/wp\/v2\/glossary"}],"about":[{"href":"https:\/\/mediconomics.com\/en\/wp-json\/wp\/v2\/types\/glossary"}],"author":[{"embeddable":true,"href":"https:\/\/mediconomics.com\/en\/wp-json\/wp\/v2\/users\/10"}],"version-history":[{"count":0,"href":"https:\/\/mediconomics.com\/en\/wp-json\/wp\/v2\/glossary\/6704\/revisions"}],"wp:attachment":[{"href":"https:\/\/mediconomics.com\/en\/wp-json\/wp\/v2\/media?parent=6704"}],"wp:term":[{"taxonomy":"glossary-cat","embeddable":true,"href":"https:\/\/mediconomics.com\/en\/wp-json\/wp\/v2\/glossary-cat?post=6704"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}